| abstract |
NEW MATERIAL:A compound of formula Ia: (R 1a is an aralkanoyl, aryloxyalkanoyl group which may be substituted, etc.; R 2 is COOH or protected COOH; Y is H or lower alkoxy group) and of formula II: (R 1 is NH 2 or substituted NH 2 ; R is hydroxymethyl, formly group, etc.; R' is H; R" is OH, halogen, etc; or may form a group =0, etc. together with R') and its salt. n EXAMPLE: 7 β-(2-Methoxyimino-2-phenyl-acetamido)-1-oxadethia-3-cephem-4-carboxylic acid (syn-isomer). n USE: Antibacterials, and intermediates for their synthesis, effective against Gram- positive and Gram-megative bacteria. n PROCESS: A compound of formula II, which is obtained from a compound of formula III: (X is halogen; R 6 is lower alkyl group) via several steps, is subjected to ring closure or oxidation to give a compound of formula IV, which is acylated, if necessary, to afford the compound of formula Ia. n COPYRIGHT: (C)1979,JPO&Japio |