| abstract |
PURPOSE: Syn-isomer of 3,7-disubstd.-3-cephem-4-carboxylic acids of formula I [R 1 is radical II (R 5 is H, halogen, etc., R 6 is OH, alkoxy, etc.), radical III (R 7 is amino, protected amino, etc.), radical IV (R 8 is alkyl; R 9 is imino, etc.); R 2 is aliphatic hydrocarbon radical; R 3 is carboxy, etc.; R 4 is methyl, acyloxymethyl, methyl, etc.] and their salts, e.g. 7-[2-methoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetamido]-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (synisomer). n COPYRIGHT: (C)1978,JPO&Japio |