| abstract |
PURPOSE: Prostaglandin I 2 (6331] analogous cpds. I (Y is trans-vinylene or ethylene; R 1 is H or 1 W 12C alkyl; R 2 is H, methyl or ethyl; R 3 is a direct bond or 1 W 4C alkylene; R 4 is H, alkyl, cycloalkyl, phenyl, etc.; the dotted line shows α-coordination, β-coordination or their mixture; the double bond between 5and 6-positions is Z), e.g. (5Z, 13E)-(9α, 15S)-6,9-epoxy-15-hydroxyprosta-5,13dienoic acid methylester. n COPYRIGHT: (C)1978,JPO&Japio |