| abstract |
PURPOSE: Prostagandin I 2 analogous cpds. I (Y is trans-vinylene or ethylene; R 1 is H or alkyl; R 2 is H, methyl or ethyl; R 3 is a direct bond or 1 - 4C alkylene; R 4 is H, alkyl, phenyl, etc.; the dotted line is α-coordination, β-coordinatio or their mixture; the double bond between 2- and 3-positions is trans, and the double bond between 5- and 6-positions is Z) or their cyclodextrin inclusion cpds. and nontoxic salts, e.g. (2E, 5Z, 13E) - (9α, 11α, 15S) -6,9-epoxy-11,15-dihydroxyprosta-2,5,13-tienic acid methylester. n COPYRIGHT: (C)1978,JPO&Japio |