| abstract |
PURPOSE: Prostaglandin X analogues I[Y is trans-vinylene or ethylene;R' is H or 1-12 alkyl;R 2 is H, methyl or ethyl;R 3 is a direct bond or 1-4C alkylene; R 4 is H, 1-8C alkyl, substd or nonsubstd 4-7C cycloalkyl, etc.; the dotted line is α-or β-coordination(S or R coordination) or their mixture; the double bond between 5 and 6-position is Z] and their nontoxic salts (R' is H), e.g. (5Z, 13E)-(9α,11α, 15α)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dienoic acid methylester. n COPYRIGHT: (C)1978,JPO&Japio |