http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H11514635-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate | 1996-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1999-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H11514635-A |
| titleOfInvention | Farnesyltransferase-inhibiting 2-quinolone derivatives |
| abstract | (57) Abstract: The present invention relates to a compound of the formula (I), a stereoisomer thereof and a pharmaceutically acceptable acid or base addition salt thereof having a farnesyltransferase inhibitory activity, wherein The dashed lines optionally represent a bond, X is oxygen or sulfur, R 1 is hydrogen, C 1-12 alkyl, Ar 1 , Ar 2 C 1-6 alkyl, quinolinyl C 1-6 alkyl, pyridyl C 1-. 6 alkyl, hydroxy C 1-6 alkyl, C 1-6 alkyloxy C 1-6 alkyl, mono- or di (C 1-6 alkyl) -amino C 1-6 alkyl, amino C 1-6 alkyl, or formula —Alk 1 —C (＝ O) —R 9 , —Alk 1 —S (O) —R 9 or —Alk 1 —S (O) 2 —R 9 , wherein R 2 and R 3 are each independently Hydrogen, hydroxy, halo, cyano, C 1-6 alkyl, C 1-6 alkyl Xy, hydroxy C 1-6 alkyloxy, C 1-6 alkyloxy-C 1-6 alkyloxy, amino C 1-6 alkyloxy, mono- or di (C 1-6 alkyl) amino C 1-6 alkyloxy Ar 1 , Ar 2 C 1-6 alkyl, Ar 2 oxy, Ar 2 C 1-6 alkyloxy, hydroxycarbonyl, C 1-6 alkyloxycarbonyl, trihalomethyl, trihalomethoxy, C 2-6 alkenyl, Or when adjacent, R 2 and R 3 may together form a divalent group, and R 4 and R 5 are each independently hydrogen, Ar 1 , C 1-6 Alkyl, C 1-6 alkyloxy-C 1-6 alkyl, C 1-6 alkyloxy, C 1-6 alkylthio, amino, hydroxycarbonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkyl S (O) C 1-6 alkyl or C 1-6 alkyl S (O) a 2 -C 1-6 alkyl, R 6 and R 7 are each independently hydrogen, halo, cyano, C 1-6 alkyl, C 1-6 alkyloxy or Ar 2 oxy, R 8 is hydrogen, C 1-6 alkyl, cyano, hydroxycarbonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkylcarbonyl C 1-6 alkyl, cyano C 1-6 alkyl, C 1-6 alkyloxycarbonyl C 1-6 alkyl, hydroxycarbonyl-C 1-6 alkyl, hydroxy C 1-6 alkyl, amino C 1-6 alkyl, mono- or di (C 1-6 alkyl) amino C 1-6 alkyl, halo C 1 -6 alkyl, C 1-6 alkyloxy-C 1-6 alkyl, aminocarbonyl C 1-6 alkyl, Ar 1 , Ar 2 C 1-6 alkyloxy C 1-6 alkyl, C 1-6 alkylthio C 1- 6 alkyl, R 10 is hydrogen, C 1-6 alkyl or halo There, R 11 is hydrogen or C 1-6 alkyl, and the present invention also relates these preparations, to the use of these as compositions and their pharmaceutical contains. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004514695-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004514677-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004516322-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004516323-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11111226-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018525444-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10653672-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2015119249-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11753387-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004517960-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11702396-B2 |
| priorityDate | 1995-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 347.