| abstract |
(57) Abstract: The present invention provides a compound represented by the formula (I): Wherein R 1 is N-pyrrolidinyl or N-piperidinyl; R 2 and R 3 are independently hydrogen, -CO- (C 10 -C 22 alkyl), -CO- (C 10 -C 22 branched alkyl), - CO- (C 10 -C 22 alkenyl), - CO- (C 10 -C 22 polyalkenyl), - CO- (C 10 -C 22 alkynyl), or -CO- (CH 2) an n COR 4 (where never both of R 2 and R 3 are dodecanoyl, also one of R 2 or R 3 is not hydrogen); R 4 is 3-cholesteryl or - O (CH 2) 2 (oR 5) be CH 2 oR 6; R 5 and R 6 are independently hydrogen, -CO- (C 10 -C 22 alkyl), - CO- (C 10 -C 22 branched alkyl), - CO- (C 10 -C 22 alkenyl), - CO- (C 10 -C 22 polyalkenyl), or -CO- (C 10 -C 22 al A sulfonyl) (provided that one of R 5 or R 6 is not hydrogen); n provides novel benzothiophene, and pharmaceutically acceptable salts and solvates thereof are 0-4] . The present invention further provides pharmaceutical compositions comprising a compound of formula (I), and the use of such a compound. |