| abstract |
(57) [Summary] The present invention relates to a compound of the formula (I) Wherein R 1 and R 2 are each independently C 1 -C 3 alkyl, or R 1 and R 2 together are a C 5 -C 6 alkylene ring or a structural formula Z is (CH x ) n , x and n are each independently 0 or an integer of 1-2; R 3 is hydrogen, C 1 -C 4 alkyl, OH, OAc or = O is a substituent selected from the group consisting of; and the ring represented by X is (Where the darker portion indicates the side attached to the nitrone ring and R 4 , R 5 , R 6 and R 7 are independently hydrogen, C 1 -C 3 alkyl, OH or C 1 -C 3 is selected from the group consisting of alkoxy). With the proviso that R 1 and R 2 together form a C 5 -C 6 alkylene ring, and when n is 1, R 3 is not hydrogen. Salts, their use in preventing oxidative tissue damage by free radicals, their use in the treatment of some disease states in which free radicals damage or destroy tissue by oxidation, and pharmaceutical compositions containing these cyclic nitrones About things. |