http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H11511123-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-5728 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-572 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-425 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-58 |
| filingDate | 1996-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1999-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H11511123-A |
| titleOfInvention | 4,9-Ethanobenzo (f) isoindole derivatives as farnesyltransferase inhibitors |
| abstract | (57) Abstract Novel products of general formula (I), their preparation and pharmaceutical compositions containing the products are disclosed. In the general formula (I), R is a group of the general formula-(CH 2 ) m -X 1- (CH 2 ) n -Z, wherein X 1 is a single bond or O or S, and m is 0 or 1 And n is 0, 1 or 2, the CH 2 group is optionally substituted with carboxy, alkoxycarbonyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, amino, alkylamino or dialkylamino, and Z is carboxy, COOR 4 , wherein R 4 is alkyl, or CON (R 5 ) (R 6 ), wherein R 5 is hydrogen or alkyl, and R 6 is hydrogen or optionally substituted alkyl; otherwise R 5 is hydrogen or alkyl, and R 6 is alkyloxy or amino which is optionally substituted hydroxy, Other is PO (OR 7) 2, wherein R 7 is hydrogen or alkyl, or group -NH-CO-T, the T in the formula is an alkyl substituted by hydrogen or, otherwise Otherwise, group (a), R 1 and R 2 are hydrogen or halogen or optionally substituted alkyloxy or alkyl, otherwise R 1 and R 2 in the ortho position are 1 or 2 R 1 is hydrogen or halogen or optionally substituted alkyloxy or alkyl, and R 2 is thioalkyl, forming a heterocyclic ring containing one or more optionally substituted heteroatoms. , R 3 is hydrogen or halogen or alkyl, alkenyl, alkyloxy, alkylthio, carboxy or alkyloxy carbonylation And a, X is O or S, or -NH -, - CO-, methylene, ethylene, alkylidene or 1,1-cycloalkyl, and Y is O or S. The novel products of general formula (I) are farnesyltransferase inhibitors which have outstanding anticancer and antitumor properties. |
| priorityDate | 1995-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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