| abstract |
(57) [Summary] Formula (I) wherein one or two of R, R 1 , R 2 and R 3 may be the same or different: (a) —X— (CH 2 ) m —NH 2 , -X- (CH 2) m -NR 4 R 5 or -X- (CH 2) m -NHR 6 group, (b) -NH-C ( = NH) -NR 4 R 5, -NH-C (= NH) -NHR 6, -N = CH -NH 2, -N = CH-NR 4 R 5 or -N = CH-NHR 6, ( c) -X- (CH 2) n -COR 7, (d) -COR a or -COR 8, (e) -Y- CO-Y'-R 9 group, tetramethylene Lil-methylene-2-oxindole derivatives having] is selected from (f) -NHR 6 or -NHR 10 group And pharmaceutically acceptable salts of the salt-forming derivatives of formula (I) above are tyrosine kinase inhibitors. |