| abstract |
(57) [Summary]nThe present invention relates to heterocyclic competitive inhibitors of the enzyme thrombin, their production, and the development of their pharmaceutical compositions. In addition, the present invention provides the compounds and compositions described above as anticoagulants in vitro and in thrombotic disorders causing acute ischemic cases such as myocardial or cerebral infarction, such as venous thrombosis, pulmonary embolism and arterial thrombosis The present invention relates to a method of using as an in vivo drug for the treatment and prevention of the disease. Furthermore, the compounds and compositions have therapeutic efficacy for the prevention and treatment of coagulopathies associated with coronary bypass surgery and restenosis cases following transluminal angioplasty. |