| abstract |
(57) Abstract: The present invention provides a method for preparing a compound of the formula I wherein R 1 is H, (β-1) GalNAc-, SO 3 B (B is H or a cation), Or a compound of the formula II wherein R 6 , R 7 , R 8 and R 10 are each independently H, C 1-6 acyl, lactyl, C 1-6 alkyl, sulfate, phosphate, anhydride, Sialic acid represented by II, (α-1) Fuc, (β-1) Glc or (β-1) Gal; R 9 is NH—C 1-6 acyl, glycolylamide, amino or hydroxyl And A is H or a cation]; R 2 is H or (α-1) Fuc-; R 3 and R 4 are each independently OH or NHAc R 5 is H, SO 3 B (B is H or a cation) or a sialic acid of formula II as defined above; and Y is a chemical bond or a bridging group; H or M is 0 or 1; and p is an integer from 1 to 1000. A method for treating a respiratory infection caused by a bacterium selected from the group consisting of S. pneumoniae, H. influenza, H. parainfluenzae, Burkholderia (Pseudomonas) cepacia and mixtures thereof, by administering a compound represented by the formula: As well as pharmaceutical compositions containing similar compounds. |