abstract |
(57) Abstract: The present invention relates to 3- [3- [3- (imidazolin-2-ylamino) propyloxy] isoxazol-5-ylcarbonyl useful as an antagonist of α v β 3 and related integrin receptors. Novel heterocyclic compounds containing [amino] -2- (benzyloxycarbonylamino) propionic acid, pharmaceutical compositions containing such compounds, methods of preparing such compounds, combining these compounds alone or with other agents The invention also relates to methods for use in the treatment of cell adhesion inhibition and angiogenic diseases, inflammation, bone degeneration, tumors, metastases, thrombosis and other conditions associated with cell aggregation. |