| abstract |
(57) [Summary]nThe present invention discloses a secreted polypeptide called osteoprotegerin that is a member of the tumor necrosis factor receptor superfamily and is involved in regulating bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies that bind to OPG, and pharmaceutical compositions. The polypeptide is used to treat a bone disease characterized by increased resorption, such as osteoporosis. |