| abstract |
(57) [Summary] The present invention relates to a compound of the formula (I) [Wherein R 1 and R 4 are hydrogen, halogen, C 1 to 6 alkyl, C 2 to 6 alkenyl, C 2 to 6 alkynyl, C 3 to 7-cycloalkyl, C 3 to 7-cycloalkyl C 1 to 4 alkyl, C 1 to 6 alkoxy or where hydroxy or whether a C 1 to 4 alkyl substituted by C 1 to 4 alkoxy groups, or OCF 3, hydroxy, trifluoromethyl, trimethylsilyl, nitro, CN, SR a, SOR a, SO 2 R a, a COR a, CO 2 R a or CONR a R b, this case R a and R b are each independently hydrogen or C 1 to 4 alkyl, R 2, R 3 and R 5 is hydrogen, halogen, or a C 1 to 6 alkyl, or is C 1 to 4 alkoxy C 1 to 6 alkoxy substituted by a group, or a trifluoromethyl, R 6, R 7 and R 8 it Is hydrogen are either independently, or a C 1 to 4 alkyl group optionally substituted by a hydroxy group, Het is = O, = optionally substituted with S or C 1 to 4 alkyl group and formula ZNR 9 R A 5- or 6-membered heterocyclic ring having 2 or 3 nitrogen atoms optionally substituted by 10 groups]. The compounds of the present invention are particularly useful for treating pain, inflammation, migraine and vomiting. |