abstract |
(57) Summary The present invention relates to novel products and methods for modulating hematopoietic cell function and novel products and methods for identifying compounds capable of modulating inflammation. The present invention includes a method for regulating hematopoietic cell function by contacting a cell with a regulatory reagent capable of altering the activity of a molecule, including PTP1C, PTP1D, ITIMp160 and ITIMp70. The present invention also relates to a control reagent that can control the activity of PTP1C, PTP1D, ITIMp160 and ITIMp70, including a reagent and a nucleic acid molecule having a sequence encoding an antibody raised against the reagent. The invention further includes a therapeutic composition comprising such a reagent and its use for protecting animals from inflammation. |