| abstract |
(57) [Summary] (1) The following general formula (1): Or a pyridyl group, and n represents 1 or 2 (where, R 3 represents a hydrogen atom, a lower alkyl group or a benzyl group; R 4 and R 5 are the same or different and each have a hydrogen atom, a lower alkyl group, a phenyl group which may have a substituent, or a substituent; An aralkyl group or a heterocyclic group which may have a substituent, and R 6 and R 7 may be the same or different and are a hydrogen atom, a lower alkyl group, a lower alkoxy group or methylenedioxy A pyrimidine derivative or a salt thereof, and a medicament containing the same as an active ingredient. [Effect] It has a strong inhibitory activity against endothelin, which has a strong vasoconstrictive action, and is useful for treating cardiovascular diseases and the like. |