| abstract |
PROBLEM TO BE SOLVED: To provide a low-density lipoprotein (LDL) An object of the present invention is to provide a urethane derivative having a receptor gene expression enhancing action or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the compound as an active ingredient. SOLUTION: A compound having a low-density lipoprotein (LDL) receptor gene expression enhancing action and having a urethane skeleton, for example, a compound represented by the general formula [Ia]: (Wherein, R 1 represents (1) a substituted or unsubstituted heterocyclic group or the like, R 2 represents a hydrogen atom or a substituted or unsubstituted alkyl group, and R 31 represents a (1) substituted or unsubstituted alkyl group or the like. , R 1 is a substituted or unsubstituted 2-quinolyl group, R 31 is (1) a linear alkyl group having 4 or more carbon atoms, or a C 1 to C 3 substituted with a heterocyclic group; Linear alkyl group or substituted or unsubstituted carbon number 4 These are the above-mentioned branched alkyl groups (however, excluding the tert-butyl group). And a urethane derivative [I- a]. |