| abstract |
(57) [Summary] (Modified)n[PROBLEMS] Activity as an inhibitor of cytokine production A series of synthetic derivatives having properties are provided.nSOLUTION: The following formula (I):n [Wherein the bond a is (II)n X is O or NH; R 1 Is Selected from the group;n-Group: R Three (O) C-n(Where R Three Is the following equation: R Four A group of -CH = CH-, wherein R Four Is C 1 −C 20 Alkyl, C Two −C 20 Alkenyl, etc.) is theren-Group: ArCH Two −nWherein Ar is an aryl group; andn-Group: R Five O-CH Two −n(Where R Five Is a C that optionally contains one or two O atoms 1 −C 6 R which is alkyl) Two Is CH Three , R 6 OOC- or R 6 NHOC − (Where R 6 Is C 1 −C 6 Is alkyl)) -A compound that is dihydro-α-pyrone; Or veterinarily acceptable salts or esters are Chemicals with activity as inhibitors of itokine production And the compounds and pharmaceutical compositions containing them. |