abstract |
(57) [Summary] (with correction) [PROBLEMS] To provide a method for introducing a dystrophin gene into skeletal muscle. The present invention provides a nucleotide sequence having at least one hinge 1, hinge 4 and rod domain of a dystrophin gene and a length of 4.5 kb or less, or hybridizing to the nucleotide sequence. A gene for treating muscular dystrophy having a base sequence which can be used, a therapeutic agent for muscular dystrophy comprising these genes, a gene transfer medium for gene therapy of muscular dystrophy comprising an adeno-associated virus (AAV) vector or a lentiviral vector, the gene described above The present invention relates to an adeno-associated virus (AAV) vector, a lentivirus vector, or an adenovirus vector, comprising: and a therapeutic agent for muscular dystrophy comprising the adenovirus. |