| abstract |
(57) [Problem] To provide a nucleic acid construct for gene therapy whose activity is affected by a cyclin-dependent kinase inhibitor. SOLUTION: Proteins that inhibit intracellular p27 and thereby reduce the inhibition of cell growth caused by p27 (including those mutants with dominant disturbing traits) And a nucleic acid construct for gene therapy comprising a nucleic acid encoding the same, and the use of these nucleic acids for the prevention and treatment of diseases. |