| abstract |
PROBLEM TO BE SOLVED: To provide a method for producing an ester derivative by a method of finally isolating a target compound without isolating an intermediate product in the middle. SOLUTION: A compound represented by the general formula (1) is aminated by a catalytic reduction reaction in an aromatic hydrocarbon solvent in the presence of a reduction catalyst to obtain 5-halo-2-hydroxy-3-aminoacetophenone. Next, after adjusting the pH with a basic substance, dehalogenation is performed by catalytic reduction to obtain 3-amino-2-hydroxyacetophenone, which is reacted with a benzoic acid halide derivative in the presence of a deoxidizing agent to obtain a compound of the general formula (6) And a method for producing an ester derivative represented by the formula (9), and the above compound is reacted with an oxalic acid diester or an alcoholate to obtain a butenoic acid derivative, which is reacted with an acid to form an ester derivative represented by the general formula (9) Manufacturing method to get. (In the formula, X represents a halogen atom.) (Wherein, R 1 represents an alkyl group having 2 to 5 carbon atoms which may be substituted with a phenyl group) (In the formula, R 2 represents an alkyl group having 1 to 4 carbon atoms.) |