| abstract |
PROBLEM TO BE SOLVED: To provide a drug having an upper and lower gastrointestinal motility-enhancing action which has little side effects and can be orally administered. SOLUTION: The following general formula: (Wherein, the R 1 is a hydrogen atom or a lower alkanoyl group, R 2 Is a halogen atom, R 3 is a lower alkoxy group, R 4 and R 5 are both hydrogen atoms or both together (C H 2 ) 2 , (CH 2 ) 3 , R 6 is a hydrogen atom or a lower alkyl group, R 7 is a lower alkanoyl group, a lower alkoxycarbonyl group, a cycloalkyloxycarbonyl group, a lower alkoxy group, a cycloalkyloxy group, etc. And m is 1 to And n represents an integer of 0 to 3. )) Or a pharmacologically acceptable salt thereof, It has excellent upper and lower gastrointestinal motility-enhancing effects, and has few side effects and can be administered orally. Therefore, it is extremely useful as a therapeutic agent for gastrointestinal diseases or an agent for improving gastrointestinal motility function. |