| abstract |
(57) [Summary] (Solution) [Problem] An OPF16 having an activity of inducing differentiation of bone marrow cells into a cell having hydroxyapatite decomposability, a similar protein of the OPF16, a peptide fragment of these proteins, an antibody A drug containing these proteins as active ingredients, a gene encoding these proteins, The expression vector of the gene, a transformant into which the expression vector has been introduced, a method for producing a recombinant protein using the transformant, a transgenic animal relating to the introduction and deletion of the gene, or a hydroxyapatite-degrading agent from bone marrow cells Use of the protein in screening for an inhibitor of a cell differentiation-inducing activity. [Effect] Since the novel protein OPF16 has an activity of inducing differentiation of bone marrow cells into cells having hydroxyapatite decomposability, it can be applied to a wide range of diseases to be treated by exerting the function. |