| abstract |
PROBLEM TO BE SOLVED: To use dehydroacetic acid, sodium salt of dehydroacetic acid or both in an aqueous preparation containing hyaluronic acid, hyaluronic acid salt or a mixture of hyaluronic acid and hyaluronic acid salt. And a method for suppressing a decrease in molecular weight due to decomposition of hyaluronic acids. SOLUTION: An aqueous preparation containing hyaluronic acid, hyaluronic acid salt or both thereof and dehydroacetic acid, sodium dehydroacetate or both thereof is mixed with ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid, trans-1,2-diaminocyclohexanetetraacetic acid, glycol. At least one selected from the group consisting of etherdiaminetetraacetic acid, citric acid and salts thereof is blended. Further, aqueous preparations are the main agents of ophthalmic agents, otolaryngological agents or ointments. |