| abstract |
(57) [Problem] To provide a novel amino acid derivative chemokine receptor antagonist. PROBLEM TO BE SOLVED: To provide an amino acid derivative represented by the following formula R 1 -XAYR 2 ... (1) wherein A represents arginine, lysine or ornithine, X does not exist, or-(C = O)- ,-(S = O)-, -SO 2- , -NH -(C = O)-, -NH- (C = S)-, Y is absent or -O -, -S- or -NR 3- . R 1 and R 2 each independently represent an alkyl residue or an alkenyl residue, or one of them represents a hydrogen atom. It has CXC and CC chemokine receptor antagonism, and exhibits excellent effects in treating or preventing AIDS, allergic diseases, inflammatory diseases and the like. |