| abstract |
PROBLEM TO BE SOLVED: To provide a tumor necrosis factor receptor (TNF) -R) related polypeptides and their ligands (hereinafter TR1, TR3, TR5 and TL3). The present invention also relates to methods for identifying agonists and antagonists of TR1, TR3, TR5, and TL3. SOLUTION: (a) Labeled or unlabeled ligand TL 3 in the presence of TR1, TR3 or TR5 Each of them; and (b) the candidate compound is TL A method of identifying an agonist or antagonist for TR1, TR3 or TR5, comprising assessing the ability to compete with TR3, TR3 or TR5, respectively. |