| abstract |
PROBLEM TO BE SOLVED: To provide a novel alkylated derivative of rapamycin having pharmaceutical utility as an immunosuppressant. SOLUTION: Formula I: embedded image Or a compound having the structural formula of 40-O- (2 -Hydroxy) ethoxycarbonylmethyl-rapamycin, 40-O-[(3S) -2,2-dimethyldioxolan-3-yl] methyl-rapamycin or 40-O- [2- (4 ', 5'-dicarbethoxy-1', 2 ', 3'-triazol-1'-yl) -ethyl] -rapamycin. |