| abstract |
(57) [Problem] To provide a novel compound having a high affinity for MDR [Constitution] [Formula 1] Wherein Ar is a pyridyl group or a compound of the formula (Wherein X 3 and X 4 are the same or different and are a hydrogen atom, a halogen atom, a C 1-5 alkyl group, a C 1-5 alkoxy group, Shows a hydroxyl group or a trifluoromethyl group. ), And Y represents a nitrogen atom, CH, or C (OH). R 1 and R 2 may be the same or different and each represent a hydrogen atom, a C 1-10 alkyl group, a C 3-15 alkoxyalkyl group, Represents an alkylaminoalkyl group of 3-15 , or R 1 and R 2 together with an adjacent nitrogen atom form a cyclic amino group. X 1 and X 2 are the same or different and each represent a hydrogen atom, a C 1-5 alkyl group, a C 1-5 alkoxy group or a halogen atom, or X 1 and X 2 are taken together to form an alkylenedioxy group To form n shows the integer of 1-3. A 1,2-dihydro-2-oxoquinoline derivative or a pharmaceutically acceptable salt thereof. |