| abstract |
(57) [Abstract] (Modified) [PROBLEMS] Hydrochloric acid containing a sustained-release hydroxypropylmethylcellulose matrix, a microcrystalline cellulose disintegrant, and a filler, formed by dry granulation and direct compression A pseudoephedrine sustained release tablet is provided. A method of making a sustained release tablet, comprising mixing an active ingredient with a lubricant and a filler to form a mixture, The mixture is milled and the mixture is screened with about 20% to 40% HPMC having a hydroxypropyl content of less than 9% and a molecular weight of less than 50K and about 25% to 50% microcrystalline cellulose to filter the composite. Forming a sustained release tablet comprising forming, mixing the composite, adding a lubricant to the composite to form a composition, and further directly compressing the composition to form a tablet. Method. |