| abstract |
(57) [Summary] Condensed piperidine compound represented by the general formula (I), a method for producing the same, and a drug containing the compound as an active ingredient (wherein -R 1- together with the carbon atom at the bonding position A 3- or 4-membered carbon ring fused to d or e of the piperidine ring or spiro-bonded to the 4-position; R 2 is C 1-6 alkyl; R 3 is C 1-6 alkyl, C 2-6 alkenyl; C2-6 alkynyl, a halogen atom; R 4 is a hydrogen atom, C1-6 alkyl, (substituted) carbocycle-C1-4 alkyl; i, n are 0-3). Embedded image The compound of the general formula (I) and salts thereof are NO It has an S inhibitory effect and is useful for the treatment and / or prevention of shock, hypotension, rheumatoid arthritis, ulcerative colitis, ischemic encephalopathy, tumor, insulin-dependent diabetes, and the like. |