| abstract |
(57) [Problem] To provide a fenofibrate-containing pharmacological composition having improved solubility and bioavailability. SOLUTION The bioavailability of fenofibrate is improved by constructing it with a solid dispersion of a disintegrant in fenofibrate. A method of making such a solid dispersion comprises melting fenofibrate, compounding the melt with a disintegrant, and re-solidifying the mixture. |