| abstract |
(57) [Summary] (Modified) [Problem] It has an ICE inhibitory effect, and has rheumatoid arthritis, Provided is a novel alkyl-substituted glycine derivative or a salt thereof useful for encephalitis, inflammatory bowel disease, pancreatitis and the like, and a medicament containing them as an active ingredient. A novel alkyl-substituted glycine derivative represented by the following general formula (I) or a salt thereof, and a medicament containing them as an active ingredient. (Wherein, R 1 : R 11 -B-CO- or R 11 -B-SO 2- Group R 11 : hydrogen atom, aryl or heteroaryl group B: lower alkylene, lower alkenylene, -lower alkylene-O-, or -lower alkenylene-O- group Ring D: aromatic hydrocarbon ring, cycloalkane, or saturated or unsaturated heterocycle n: integer of 0-2 m: integer of 1-5 R 2 : hydrogen atom, hydroxy, lower alkyl, lower alkenyl, etc. |