| abstract |
(57) [Summary] (Modified) [Problem] Stroke, post-stroke cerebral edema and asthma, chronic bronchitis, shock, rheumatoid arthritis, reperfusion injury (reperf The present invention provides novel nicotinamide derivatives useful for the prevention, treatment or amelioration of various allergic and inflammatory diseases such as erythritis and encephalomyelitis and multiple sclerosis. A compound of the following general formula (1) or a pharmacologically acceptable salt thereof. Wherein R 1 is a hydrogen atom or a lower alkyl group, R 2 is a group of the following formula, R 3 represents a group represented by the following formula, R 4 represents a hydrogen atom or a lower alkyl group] |