| abstract |
[PROBLEMS] To provide a method for efficiently producing an optically active amine derivative with high purity and high yield on a large scale. SOLUTION: The formula: [Wherein, R 1 and R 2 each represent a hydrogen atom, a hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, or R 1 and R 2 are X may be a spiro ring which may have a substituent together with an adjacent carbon atom, and X is (CH 2 ) n (n is 1 to 4 Represents an integer), a nitrogen atom, an oxygen atom or a sulfur atom, and m represents an integer of 1 to 3. Ring A may have a substituent. A compound or a salt thereof, Asymmetric hydrogenation reaction in the presence of a transition metal-optically active phosphine complex; Wherein each symbol is as defined above. And a method for producing an optically active form of the compound or a salt thereof. |