| abstract |
Abstract: Factors that can be used to screen compounds for antibiotic activity and that can be used to determine their role in the pathogenesis of infection, dysfunction and disease are disclosed. Is desired. The present invention provides an isolated polynucleotide consisting of a polynucleotide having at least 70% identity to a polynucleotide encoding a polypeptide consisting of the amino acid sequence of SEQ ID NO: 2 or 4; Polynucleotides encoding polypeptides and gidA2 polypeptides and methods for their production by recombinant techniques. Further, there is provided a method of utilizing a gidA2 polypeptide to screen for antimicrobial compounds. |