| abstract |
(57) [Problem] To provide cDNA of a human HD gene homolog in minipigs and various genetic engineering materials related thereto. SOLUTION: The cDNA of the miniature pig huntingtin gene having the nucleotide sequence of SEQ ID NO: 1 and its CAG / C AA polymorphism sequence, a DNA fragment consisting of a partial sequence of these cDNAs, a recombinant vector carrying each cDNA, a mini swine huntingtin gene to which each cDNA or DNA fragment hybridizes, SEQ ID NO: 2 encoded by each cDNA An antibody prepared as a mini-pig huntingtin-related protein having the following amino acid sequence, a peptide consisting of a partially continuous sequence of these proteins, a protein or a peptide immunogen. |