| abstract |
[PROBLEMS] To provide a dibenzocycloheptene derivative having an aldose reductase inhibitory effect which is effective for prevention and treatment of diabetic complications. SOLUTION: General formula 1 [R1 and R2 independently represent a hydroxyl group, a lower alkoxy group which may be substituted by an aryl group, or a halogen, provided that when one of them is a halogen, the other represents a hydroxyl group; R3 and R4 represent one hydrogen and the other hydroxymethyl Represents a lower alkylaminomethyl, carboxy lower alkylaminomethyl, dioxothiazolidylidenemethyl, carboxyl, formyl, oxo-4H-oxadiazole group, or R3 And R4 both represent or are linked to oxygen to form a tetrahydrofuran, tetrahydrothiophene, pyrrolidine, imidazolidine, pyrazolidine, thiazolidine, oxazolidine, cyclopentane, oxathiolane, pyrrolidinedione, tetrahydrofurandion ring. ] The dibenzocycloheptene derivative of the above. |