| abstract |
PROBLEM TO BE SOLVED: To provide a spherical fine particle aggregate of alginic acid, which can be used as a carrier in various fields such as medicine, food, chemical industry, agrochemicals, etc., a production method thereof, a controlled release preparation using the carrier, and the like. SOLUTION: An aqueous solution of a polyvalent metal salt is added to a water-in-oil emulsion obtained by emulsifying and dispersing an aqueous solution of alginic acid and / or its sodium in a non-aqueous solvent containing a polyhydric alcohol fatty acid ester as a main component. A spherical fine particle aggregate of a salt is formed, and a suspension of the spherical fine particle aggregate in water is spray-dried to produce a spherical fine particle aggregate of a polyvalent metal alginate. A controlled release preparation is prepared by supporting a poorly soluble drug on the aggregate of spherical fine particles. |