| abstract |
Abstract: Factors that can be used to screen compounds for antibiotic activity and that can be used to determine their role in the pathogenesis of infection, dysfunction and disease are disclosed. Is desired. The present invention provides a polynucleotide having at least 70% identity to a polynucleotide encoding a polypeptide comprising the amino acid of SEQ ID NO: 2, which can be used to solve the above problem. And a histidine kinase polypeptide and a polynucleotide encoding the histidine kinase polypeptide, and a method for producing the polypeptide by recombinant techniques. Further, there is provided a method of utilizing a histidine kinase polypeptide to screen for antimicrobial compounds. |