| abstract |
(57) [Summary] [PROBLEMS] By activating metabolic activity of dermal fibroblasts and preventing damage to fibroblasts by ultraviolet rays, generation of wrinkles and spots due to various stresses such as aging and ultraviolet rays, Provided is an external preparation for preventing aging, which is effective for preventing or improving skin aging symptoms such as a decrease in skin elasticity, and also has an anti-inflammatory action and a wound healing promoting action. SOLUTION: Salicin and one or more selected from the group consisting of α-hydroxy acids, salts and derivatives thereof are used in combination as active ingredients. Salicin is Saligenin-β-D-glucoside is a kind of phenol glycoside and is a component abundantly contained in the bark, leaves and female flowers of Salicae plants. The combined use of salicin and α-hydroxy acids synergistically improves the metabolic activity of dermal fibroblasts. |