http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H11100354-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b09f893b262cefd50c5e76c4b85d1c0a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-347 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-347 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-347 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-12 |
| filingDate | 1998-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa0920da457dbda174e4f7f57885b37a |
| publicationDate | 1999-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H11100354-A |
| titleOfInvention | Method for producing cyclobutane-1,2-dicarboxylic acid ester |
| abstract | (57) [Summary] (Modified) [Solution] General formula I Of cyclobutane-1,2-dicarboxylic acid ester (R 1 C 1 -C 8 alkyl groups, unsubstituted or optionally monocyclic or bicyclic C3~10 cycloaliphatic group, an aryl which may be substituted or an arylalkyl group or an optionally substituted saturated heterocyclic group And R 2 is either a C 1 -C 4 alkyl group or two R 2 groups together forming — (CH 2 ) n —, where n is an integer from 2 to 4. )), The corresponding ester of maleic acid or fumaric acid is reacted with ketene acetal in the presence of a Lewis acid and a sterically hindered base. If an optically active ester of maleic acid or fumaric acid is used, it reacts stereoselectively. The present invention can be carried out at a low temperature without requiring a large excess of dialkylaluminum chloride. The product cyclobutane-1,2-dicarboxylate, especially in the trans configuration, is an intermediate for the synthesis of pharmacologically active compounds. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2003073338-A |
| priorityDate | 1997-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.