abstract |
(57) [Summary] (Modified) [Solution] General formula (I) [Wherein, D represents a carbon atom or a nitrogen atom, E represents a CH or a nitrogen atom, G represents an oxygen atom, a sulfur atom, a nitrogen atom or NH, Y represents an H or a halogen atom, n Represents an integer of 1 to 4, and R 1 represents the following formulas (i) to (iv) (Wherein, R 2 is H, alkyl, amino, etc .; Ar is substituted or unsubstituted phenyl or thienyl; R 3 is alkyl; X 1 and X 2 are different from each other; X 3 and X 4 are different from each other and are a nitrogen atom or NH, R 4 represents H, SH, or alkylthio. Or a pharmaceutically acceptable salt thereof. [Effect] The above compound shows affinity for dopamine D 4 receptor, but has low affinity for dopamine D 2 receptor, shows excellent separability, and has an adverse effect on extrapyramidal disorders. It is useful as an agent for preventing and treating diseases such as schizophrenia without symptoms and behavioral problems associated with senile dementia. |