| abstract |
[PROBLEMS] Arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis, or other diseases characterized by matrix metalloproteinase activity, and Preparation of cyclic sulfone derivatives useful for treating AIDS, sepsis, septic shock, and other diseases including the production of tumor necrosis factor (TNF). SOLUTION: General formula I Compound. A specific example of a compound of general formula I is N-hydroxy-3- (4-phenoxy-benzenesulfonyl) -bicyclo [2,2,2] octane-2-carboxamide. |