| abstract |
(57) [Summary] [Solution] General formula: Wherein, R 1 is phenyl or the like, A 1 is -A 4 - (CO) n - (A 4 is lower alkylene, n represents 0 or 1) or the like, R 2 is hydroxyl group, etc. R 7 is a hydrogen atom, A 2 is lower alkylene, etc., R 3 is lower alkyl, etc., A 3 is imidazolylmethyl diyl and the like, R 4 is a hydrogen atom or the like; m is 0 or 1] and a pharmaceutically acceptable salt thereof. [Effect] The compound of the present invention has a strong inhibitory activity on NO production, and thus is useful for prevention and treatment of NO-mediated diseases. |