| abstract |
PROBLEM TO BE SOLVED: To selectively act on thrombin, to exert an inhibitory action shortly after administration (preferably oral administration) independently of antithrombin III, and to exert an inhibitory action and maintain hemostasis. To provide an anticoagulant that does not interfere with the dissolution of the clot that is to be obtained. A formula (I): X-C ( O) -Y-C (O) -NH-CH 2 -G-Im represented by I compound or a pharmaceutically acceptable salt thereof, such compounds Or methods for producing salts and intermediates, pharmaceutical compositions containing such compounds or salts, and methods of using such compounds or salts as thrombin inhibitors, coagulation inhibitors and therapeutic agents for thromboembolic disorders. |