| abstract |
(57) [Summary] (with correction) [PROBLEMS] To provide a method for suppressing a pathological condition by an estrogen agonist. The compound of the following general formula I Is Alzheimer's disease, premenstrual syndrome, peri-menopause syndrome, It is useful for treating or preventing thrombomodulin deficiency, uterine fibrosis, excess myeloperoxidase activity, excess thrombin, autoimmune diseases, reperfusion injury of ischemic myocardium, and testosterone deficiency. To show a specific example of the compound, Cis-6- (4-fluoro-phenyl) -5- [4- (2-Piperidin-1-yl-ethoxy) -phenyl] -5,6,7,8-Tetrahydro-naphthalen-2-ol. |