| abstract |
PROBLEM TO BE SOLVED: To provide a novel benzothiophene and its intermediate, and its use and preparation, which inhibit PAI-1 or a pathological condition related thereto in humans. SOLUTION: Formula I: embedded image Wherein R 1 , R 2 and R 3 are independently —OH, —OC O (C 1 -C 6 alkyl), - O (CO) O (C 1 -C 6 alkyl), - OCO-Ar [Ar is phenyl or substituted phenyl, or -O (CO) O-phenyl And R 4 is N-pyrrolidinyl, N-piperidinyl, or N-hexamethyleneimino], or a pharmaceutically acceptable salt or solvate thereof, in humans with PAI-1 Or it is useful for inhibiting pathological symptoms associated therewith. |