| abstract |
[PROBLEMS] To provide a sulfur-containing heterocyclic compound useful as a bradykinin antagonist and a method for producing the same. SOLUTION: The following formula (I) Wherein one of the X 1 , X 2 or X 3 groups is C—O—R 2 In each case, the other X 1 , X 2 and X 3 , and further X 4 are the same or different and are N or CR It is 1; R 1 and R 3 are the same or different H, halogen, (C 1 ~C 6) - alkyl, O-R 6, S- R 6, NH R 6 , (C 6 -C 12 ) -aryl, (C 6 -C 12 ) -aryl- (C 1 -C 3 ) -alkyl and the like, wherein alkyl, Aryl and alkenyl can be optionally substituted; R 2 has the formula (II) A compound represented by the formula: |