| abstract |
PROBLEM TO BE SOLVED: To provide a carbamoyl-substituted heterocyclic compound having a thromboxane receptor antagonistic activity and / or a thromboxane synthase inhibitory activity, a pharmaceutical composition containing the compound, and a method for using them. SOLUTION: Formula I: embedded image Ω-phenyl-ω- (3-pyridyl) -ω-alkenoic acid derivative having a carbamoyl-substituted oxazolyl or oxazolinyl group on the phenyl ring, for example, (E) -7- [4- [4- [[(4- (cyclohexylbutyl) amino] carbonyl] -2-oxazolyl] phenyl] -7- (3-pyridyl) hept-6-enoic acid, and pharmaceutical compositions containing such compounds. |